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Glucagonlike peptide1 receptor agonists and mental health: A metaanalysis of randomized controlled trials Silverii 2024 Diabetes, Obesity and Metabolism Wiley Online Library Randomized, placebo controlled trials of the glucagon like peptide 1 (GLP 1) receptor agonists have provided strong GLP 1 agonist Liraglutide prevents MK801induced schizophrenialike behaviors and BDNF, CREB, p CREB, Trk B expressions in the hippocampus and prefrontal cortex in Balb c mice ScienceDirect The clinically most relevant mechanisms of action of GLP 1, glucagon Download Scientific Diagram GLP 1 and the kidney: from physiology to pharmacology and outcomes in diabetes Nature Reviews Nephrology Prescribing pearls: A guide to SGLT2 inhibitors DiabetesontheNet
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4.7 ★★★★★
Based on 1531 reviews
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Product Reviews
★★★★★ 5
Great chew toy to keep around the house
Color: Blue/Medium, Size: Blue, Color: Blue/Medium, Size: Blue
This came highly recommended by the behavioural team at the animal shelter and it hasn't disappointed. It's interesting reading the reviews, because our power-chewer pit-mix who can get a chunk off a split antler in a matter of minutes, hasn't ever been able to get a bite out of this bone! This is a great play toy for her, because it's soft enough that we can throw it for her to fetch in the house without worrying about breaking/denting something and are able to pull it out of her mouth fairly easily once she brings it back (still hasn't learned "drop it!"). The bone isn't flavored, so she'll rarely go to it on her own to chew on, but we keep it near the couch so if she ever gets bitey, we have it close at hand to offer to her as a chewer. It's also entertaining to tuck it into her collar and have her figure out how to remove it to play with it (see photo for this game and size compared to 50lb mutt).
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 15, 2017
★★★★★ 5
Best bouncy bone!
Color: Orange/Large, Size: Orange, Color: Orange/Large, Size: Orange
My pups love these bones! They are soft and rubbery, but very durable. Had them for a little over 6 months and it has survived my extreme chewers and many tug of war games, and only has a few puncture marks! They bounce on my concrete floors and my pup loves to play fetch with this. Great purchase
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Reviewed in the United States on April 27, 2025
★★★★★ 4
Excellent for aggressive chewers
Color: Blue/Medium, Size: Blue
First I would like to say I think Jolly Pets are the best line of dog toys out there if you have an aggressive chewer. Their products have amazed me! And I am not being paid for this review. I have a 155 lb mastiff that is an excellent behaved boy but loves to destroy his toys. I had this bone in large and it held up excellent for about 4-5 months. I ordered it again in medium size by mistake and after 2 weeks it already has pieces missing...my fault. My only complaint is the medium size in blue smells like vanilla perfume. I can't wash it off. Although my handsome boy doesn't seem to mind. I just reordered in large. Also ordered a few other Jolly Pet toys as I am amazed at how they hold up. The "soccer ball" is my dogs favorite. It reinflates itself again and again no matter how much chewing or wear and tear its given. It's just magic!
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Reviewed in the United States on October 1, 2022
★★★★★ 5
This company makes great toys for pitts!!
Color: Blue/Medium, Size: Blue, Color: Blue/Medium, Size: Blue
Our pitt LOVES this toy. The rubber is reeeaally tough. It’s well designed because it’s a slippery surface. You can tell from the video there’s a lot of squeaking from him trying to get a good grip. He found a pretty good spot to hook his upper teeth into the crevasse, but his bottom teeth kept slipping.
As a side note, I wouldn’t leave any toy home alone with him that’s about 3 inches or smaller because dogs can choke on it, but that doesn’t make this any toy or company any less amazing. For toys I would leave home with a power chewer, take a look at that 4inch red ball made by this same company. He hasn’t made a dent in that thing and you can put treats in it. :)
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Reviewed in the United States on March 5, 2025
★★★★★ 1
No for aggressive chewer waste of money
Color: Blue/Medium, Size: Blue, Color: Blue/Medium, Size: Blue
Within 10 minutes she destroyed it
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Reviewed in the United States on June 1, 2026
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